diff --git a/test/sequential/sequential.status b/test/sequential/sequential.status
index 81a152ffa0ce67..439fa2e3cd0f22 100644
--- a/test/sequential/sequential.status
+++ b/test/sequential/sequential.status
@@ -51,3 +51,17 @@ test-tls-psk-client: PASS, FLAKY
 [$arch==arm]
 # https://github.com/nodejs/node/issues/49933
 test-watch-mode-inspect: SKIP
+
+[$system==linux && $arch==ppc64]
+# https://github.com/nodejs/node/issues/59561
+test-single-executable-application: SKIP
+test-single-executable-application-assets: SKIP
+test-single-executable-application-assets-raw: SKIP
+test-single-executable-application-disable-experimental-sea-warning: SKIP
+test-single-executable-application-empty: SKIP
+test-single-executable-application-exec-argv: SKIP
+test-single-executable-application-exec-argv-empty: SKIP
+test-single-executable-application-snapshot: SKIP
+test-single-executable-application-snapshot-and-code-cache: SKIP
+test-single-executable-application-snapshot-worker: SKIP
+test-single-executable-application-use-code-cache: SKIP